New book on the SCENTIFIC BACKGROUND of INTEGRATIVE MEDICINE

Peter Heusser
Anthroposophy and Science (pdf)

Study results Anthroposophic Medicine

Recent study results

Erfahrungen am Lebensende: Eine Umfrage bei Ärzten und Pflegenden eines Spitals für anthroposophisch erweiterte Medizin. Klein S, Kohler S, Krüerke D, Templeton A, Weibel A, Haraldsson E, Nahm M, Wolf U; Complementary Medicine Research 2018 25:38-43. https://doi.org/10.1159/000478090

A 4-year non-randomized comparative phase–IV study of early rheumatoid arthritis: integrative anthroposophic medicine for patients with preference against DMARDs versus conventional therapy including DMARDs for patients without preference. Hamre H J, Pham Van N, Kern Ch, Rau R, Klasen J, Schendel U, Gerlach L, Drabik A, Simon L; Patient Preference and Adherence 2018 12: 375-97 DOI: https://doi.org/10.2147/PPA.S145221

Integrative cancer care in a certified Cancer Centre of a German Anthroposophic hospital. Thronicke A, Li Oei S, Merkle A, Herbstreit C, Lemmens HP, Grah C, Kröz M, Matthes H, Schad F; Complementary Therapies in Medicine 2018 DOI: https://doi.org/10.1159/000478655

Spiritual needs of mothers with sick new born or premature infants– A cross sectional survey among German mothers. Büssing A, Waßermann U, Hvidt N Ch, Längler A, Thiel M; Australian College of Midwives 2017 DOI: https://doi.org/10.1016/j.wombi.2017.08.002

Impact of a combined multimodal-aerobic and multimodal intervention compared to standard aerobic treatment in breast cancer survivors with chronic cancerrelated fatigue - results of a three-armed pragmatic trial in a comprehensive cohort design. Kröz M, Reif M, Glinz A, Berger B, Nikolaou A, Zerm R, Brinkhaus B, Girke M, Büssing A, Gutenbrunner C, and On behalf of the CRF-2 study group. BMC Cancer (2017) 17:166. DOI 10.1186/s12885-017-3142-7. Full article Open Access: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335840/

Impact of a combined multimodal-aerobic and multimodal intervention compared to standard aerobic treatment in breast cancer survivors with chronic cancerrelated fatigue - results of a three-armed pragmatic trial in a comprehensive cohort design. Kröz M, Reif M, Glinz A, Berger B, Nikolaou A, Zerm R, Brinkhaus B, Girke M, Büssing A, Gutenbrunner C, and On behalf of the CRF-2 study group. BMC Cancer (2017) 17:166. DOI 10.1186/s12885-017-3142-7. Full article Open Access: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335840/

Studies sorted by topics/medical speciality

(List is not complete)

Reviews

A systematic literature review on the effectiveness of eurythmy therpy.
Lötzke D, Heusser P, Büssing A. J Integr Med. 2015 Jul;13(4):217-30. doi: 10.1016/S2095-4964(15)60163-7. http://www.ncbi.nlm.nih.gov/pubmed/25808905

Anthroposophic Medicine: An Integrative Medical System Originating in Europe. Kienle GS, Albonico H-U, Baars, Hamre HJ, Zimmermann P and Kiene H. Global Adv Health Med. 2013;2(6):20-31. DOI: 10.7453/gahmj.2012.087

Overview of the Publications From the Anthroposophic Medicine Outcomes Study (AMOS): A Whole System Evaluation Study. Hamre HJ, Kiene H, Ziegler R, Tröger W, Meinecke C, Schnürer C, Vögler H, Glockmann A, Kienle S: Global Adv Health Med. 2014;3(1):54-70. DOI: 10.7453/gahmj.2013.010.
Full article: http://www.gahmj.com/doi/pdf/10.7453/gahmj.2013.010

Arts Therapies for Anxiety, Depression, and Quality of Life in Breast Cancer Patients: A Systematic Review and Meta-Analysis. Boehm K, Cramer H, Staroszynski T and Ostermann T: Hindawi Publishing Corporation. Evidence-Based Complementary and Alternative Medicine.Volume 2014, Article ID 103297, 9 pages http://dx.doi.org/10.1155/2014/103297

Klinische Forschung zur Anthroposophischen Medizin – Update eines «Health Technology Assessment»-Berichts und Status Quo. Kienle GS, Glockmann A, Grugel R, Hamre HJ, Helmut Keine H: Forsch Komplementmed 2011;18:4-4 (DOI: 10.1159/000331812).

Influence of Viscum album L (European Mistletoe) Extracts on Quality of Life in Cancer Patients: A Systematic Review of Controlled Clinical Studies. Kienle GS and Kiene H. Integrative Cancer Therapies 2010:1-16.

Clinical research in anthroposophic medicine. Hamre HJ, Kiene H, Kienle GS. Altern Ther Health Med 2009;15(6):52-55.

Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research. Kienle GS, Glockmann A, Schink M and Kiene H: Journal of Experimental & Clinical Cancer Research 2009;28:79.

Survival of cancer patients treated with mistletoe extract (Iscador): a systematic literature review. Ostermann T, Raak C, Büssing A BMC Cancer 2009, 9:451 (pp. 1-9) (http://www.biomedcentral.com/1471-2407/9/451) read more... Comment on Mistletoe therapy in oncology (Cochrane Review 2008) IFAEMM: Kiene, Kienle 2008 read more...

Complementary cancer therapy: a systematic review of prospective clinical trials on anthroposophic mistletoe extract. Kienle GS, Kiene H. Eur J Med Res 2007;12:103-19.

Anthroposophic Medicine, Effectiveness, utility, costs, safety. Kienle GS, Kiene H, Albonico HU. . Schattauer, Stuttgart, New York, 2006.

Mistletoe in cancer – a systematic review on controlled clinical trials. Kienle GS, Berrino F, Bussing A, Portalupi E, Rosenzweig S, Kiene H. Eur J Med Res 2003;8(3):109-19.

Preclinical studies

Immunomodulatory effects of preparations from anthroposophical medicine for parenteral use.
Gründemann, C.; Diegel, C.; Sauer, B.; Garcia-Käufer, M.; Huber, R. 2015. Immunomodulatory effects of preparations from Anthroposophical Medicine for parenteral use. BMC Complement Altern Med 15: 219. doi:10.1186/s12906-015-0757-6. http://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0757-6 

Clinical studies

Allergology

Allergic disease and sensitization in Steiner school children. Floistrup H, et al. The Parsifal Study Group. J Allergy Clin Immunol. 2006 Jan;117(1):59-66. Epub 2005 Nov 28.

Atopy in children of families with an anthroposophic lifestyle. Alm JS, Swartz J, Lilja G, Scheynius A, Pershagen G. Lancet. 1999 May 1;353(9163):1485-8. (1999)

Allergic disease and sensitization in Steiner school children. Floistrup H, Swartz J, Bergstrom A, Alm JS, Scheynius A, van Hage M, Waser M, Braun-Fahrlander C, Schram-Bijkerk D, Huber M, et al. J Allergy Clin Immunol 2006;117(1):59-66.

Bacterial and fungal agents in house dust and wheeze in children: the PARSIFAL study. Schram-Bijkerk D, Doekes G, Douwes J, Boeve M, Riedler J, Ublagger E, von Mutius E, Benz MR, Pershagen G, van Hage M, et al. Clin Exp Allergy 2005;35(10):1272-1278.

Bacterial and fungal components in house dust of farm children, Rudolf Steiner school children and reference children--the PARSIFAL Study.Schram D, Doekes G, Boeve M, Douwes J, Riedler J, Ublagger E, von Mutius E, Budde J, Pershagen G, Nyberg F, et al. Allergy 2005;60(5):611-618.

An anthroposophic lifestyle and intestinal microflora in infancy. Alm JS, Swartz J, Bjorksten B, Engstrand L, Engstrom J, Kuhn I, Lilja G, Mollby R, Norin, E, Pershagen G, Reinders C, Wreiber K, Scheynius A . Pediatr Allergy Immunol 2002;13(6) :402-11.

Cardiology

Training effect of eurythmy therapy on specific oscillations of heart rate variability.
Edelhäuser, F.; Minnerop, A.; Trapp, B.; Büssing, A.; Cysarz, D. 2015. Eurythmy therapy increases specific oscillations of heart rate variability. BMC Complement Altern Med 2015: 167. doi:10.1186/s12906-015-0684-6. http://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0684-6

Eurythmy therapy increases specific oscillations of heart rate variability. Edelhäuser F, Antje Minnerop A, Trapp B, Büssing A 3 and Cysarz D. BMC Complementary and Alternative Medicine (2015) 15:167 DOI 10.1186/s12906-015-0684-6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457978/

Anwendung von Cardiodoron® bei Patienten mit funktionellen Herz-Kreislauf-Beschwerden und/oder Schlafstörungen – Ergebnisse einer prospektiven, nichtinterventionellen Beobachtungsstudie. Claudia Rother,C. Forsch Komplementmed 2013;20:334–344 Published online: October 21, 2013 DOI: 10.1159/000355255

Endocrinology

Effect of Colchicum autumnale in patients with goitre and euthyroidism or mild hyperthyroidism.
Scheffer, C.; Debus, M.; Heckmann, C.; Cysarz, D.; Girke, M. 2016. Colchicum autumnale in Patients with Goitre with Euthyroidism or Mild Hyperthyroidism: Indications for a Therapeutic Regulative Effect – Results of an Observational Study. Evid Based Complement Alternat Med 2016: 2541912. doi:10.1155/2016/2541912. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756131/

Gastroenterology

Improvement of Asthma and Gastroesophageal Reflux Disease With Oral Pulvis stomachicus cum Belladonna, a Combination of Matricaria recutita, Atropa belladonna, Bismuth, and Antimonite: A Pediatric Case Report. von Schoen-Angerer T,  Madeleyn R, Kiene H, Kienle GS, Vagedes J. 2015 http://www.gahmj.com/doi/full/10.7453/gahmj.2015.019

General Medicine

Patient-centered outcomes on quality of life and Anthroposophic healthcare: a qualitative triangulation study. Koster EB, Baars EW and Delnoij DMJ. Qual Life Res. 2016. DOI 10.1007/s11136-016-1276-8 http://link.springer.com/article/10.1007/s11136-016-1276-8

Influence of spirituality on cool down reactions, work engagement, and life satisfaction in anthroposophic health care professionals. Büssing A, Lötzke D, Glöckler M, Heusser P. 2015. Influence of spirituality on cool down reactions, work engagement, and life satisfaction in anthroposophic health care professionals. Evid Based Complement Alternat Med. doi: 10.1155/2015/754814. https://www.hindawi.com/journals/ecam/2015/754814/

Patients whose GP knows complementary medicine tend to have lower costs and live longer. Peter Kooreman P and Baars EW (2010): Eur J Health Econ DOI 10.1007/s10198-011-0330-2

Sleep quality in pregnancy during treatment with Bryophyllum pinnatum: An observational study. Lambrigger-Steiner C, Simões-Wüst AP, Kuck A, Fürer K, Hamburgere M and von Mandach U. Phytomedicine 2014; 21: 753–757. http://dx.doi.org/10.1016/j.phymed.2013.11.003

Improvement of sleep quality during treatment with Bryophyllum. Simoes-Wüst, A.P.; Hassani, T.A.; Müller-Hübenthal, B.; Pittl, S.; Kuck, A.; Meden, H.; Eberhard, J.; Decker, M.; Fürer, K.; von Mandach, U.; Bryophyllum Collaborative Group. 2015. Sleep Quality Improves During Treatment with Bryophyllum pinnatum: An Observational Study on Cancer Patients. Integr Cancer Ther 2015; 14(5): 452–459. doi:10.1177/1534735415580680. https://www.ncbi.nlm.nih.gov/pubmed/25873294

Anthroposophic therapies in chronic disease: the Anthroposophic Medicine Outcomes Study (AMOS) Hamre HJ, Becker-Witt C, Glockmann A, Ziegler R, Willich SN, Kiene H. Eur J Med Res. 2004 Jul 30;9(7):351-60. read more.

Anthroposophic therapy for children with chronic disease: a two-year prospective cohort study in routine outpatient settings. Hamre HJ, Witt CM, Kienle GS, Meinecke C, Glockmann A, Willich SN, Kiene H. BMC Pediatr 2009;9:39 read more

Predictors of outcome after 6 and 12 months following anthroposophic therapy for adult outpatients with chronic disease: a secondary analysis from a prospective observational study. Hamre HJ, Witt CM, Kienle GS, Glockmann A, Willich SN, Kiene H. BMC Research Notes 2010 Aug 3;3(218). read more

Long-term outcomes of anthroposophic therapy for chronic low back pain: A two-year follow-up analysis. Hamre HJ, Witt CM, Kienle GS, Glockmann A, Ziegler R, Willich SN, Kiene H. Journal of Pain Research 2009;2:75-85. read more

Outcome of anthroposophic medication therapy in chronic disease: A 12-month prospective cohort study. Hamre HJ, Witt CM, Glockmann A, Ziegler R, Kienle GS, Willich SN, et al. Drug Design, Development and Therapy 2008;2:25-37.

Anthroposophic vs. conventional therapy for chronic low back pain: a prospective comparative study. Hamre H, Witt CM, Glockmann A, Ziegler R, Willich SN, Kiene H. Eur J Med Res 2007;12:302-10.

Anthroposophic medical therapy in chronic disease: a four-year prospective cohort study. Hamre HJ, Witt CM, Glockmann A, Ziegler R, Willich SN, Kiene H. BMC Complement Altern Med 2007;7(10):DOI 10.1186/1472-6882-7-10.

Anthroposophic therapy for attention deficit hyperactivity: a two-year prospective study in outpatients. Harald J Hamre, Claudia M Witt, Gunver S Kienle, Christoph Meinecke, Anja Glockmann, Renatus Ziegler, Stefan N Willich, Helmut Kiene. International Journal of General Medicine 2010:3 239–253.

Geriatry

Anthroposophy and Integrative Care at the End of Life. Ciro Augusto Floriani CA. Alternative and complementary therapies. 2016; 22(3): DOI: 10.1089/act.2016.29055.caf http://online.liebertpub.com/doi/abs/10.1089/act.2016.29055.caf

Usage of Complementary and Alternative Medicine Interventions by German Older Adults. Büssing A, Ostermann T, Heusser P, Matthiessen PF: J Altern Complement Med. 2011; 17(6):487-489

Pharmacotherapy of elderly patients in everyday anthroposophic medical practice: a prospective, multicenter observational study. Jeschke E, Ostermann T, Vollmar HC, Tabali M, Kröz M, Bockelbrink A, Witt CM, Willich SN, Matthes H. BMC Geriatrics 2010, 10:48. read more...

The self regulation questionnaire as a measure in quality of life research.Büssing A, Girke M, Heckmann C, Matthiesen P, Schad F, Ostermann T, Kröz M. Eur J Med Res 2009, 14(5):223-227. read more...

Health Care and Health Policies

Patient-centered outcomes on quality of life and Anthroposophic healthcare: a qualitative triangulation study. Koster EB, Baars EW and Delnoij DMJ. Qual Life Res. 2016. DOI 10.1007/s11136-016-1276-8 http://link.springer.com/article/10.1007/s11136-016-1276-8

Health services research of integrative oncology in palliative care of patients with advanced pancreatic cancer. Axtner J , Steele M, Kröz M, Spahn G, Matthes H and Schad F. BMC Cancer (2016) 16:579 DOI 10.1186/s12885-016-2594-5. https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2594-5

Opposite Drug Prescription and Cost Trajectories following Integrative and Conventional Care for Pain – A Case-Control Study. Sundberg, Petzold M, Kohls N and Falkenberg T. PLoS ONE 2014; 9(5): e96717. doi:10.1371/journal.pone.0096717.

Infectious Diseases

Integrative versus Conventional Therapy of Chronic Otitis Media with Effusion and Adenoid Hypertrophyin Children: A Prospective Observational Study. Szoeke H, Maródi M, Sallay Z, Székely B, Sterner MG and  Hegyi G.: Forsch Komplementmed 2016;23:231–239. DOI: 10.1159/000448440. http://www.karger.com/Article/PDF/448440

Antibiotic Use in Children with Acute Respiratory or Ear Infections: Prospective Observational Comparison of Anthroposophic and Conventional Treatment under Routine Primary Care Conditions. Hamre HJ, Glockmann A, Schwarz R, Riley DS, Baars EW, Kiene H and Kienle GS. Evidence-Based Complementary and Alternative Medicine Volume 2014 (2014), Article ID 243801, 17 pages Full article open access: http://dx.doi.org/10.1155/2014/243801

Use and safety of anthroposophic medications for acute respiratory and ear infections: a prospective cohort study. Hamre HJ, Glockmann A, Fischer M, Riley D, Baars E, Kiene H. . Drug Target Insights 2007;2:209-19.

Internal Medicine

Effect of Colchicum autumnale in patients with goitre and euthyroidism or mild hyperthyroidism.
Scheffer, C.; Debus, M.; Heckmann, C.; Cysarz, D.; Girke, M. 2016. Colchicum autumnale in Patients with Goitre with Euthyroidism or Mild Hyperthyroidism: Indications for a Therapeutic Regulative Effect – Results of an Observational Study. Evid Based Complement Alternat Med 2016: 2541912. doi:10.1155/2016/2541912. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756131/

Neurology

Sleep quality in pregnancy during treatment with Bryophyllum pinnatum: An observational study. Lambrigger-Steiner C, Simões-Wüst AP, Kuck A, Fürer K, Hamburgere M and von Mandach U. Phytomedicine 2014; 21: 753–757. http://dx.doi.org/10.1016/j.phymed.2013.11.003

Improvement of sleep quality during treatment with Bryophyllum. Simoes-Wüst, A.P.; Hassani, T.A.; Müller-Hübenthal, B.; Pittl, S.; Kuck, A.; Meden, H.; Eberhard, J.; Decker, M.; Fürer, K.; von Mandach, U.; Bryophyllum Collaborative Group. 2015. Sleep Quality Improves During Treatment with Bryophyllum pinnatum: An Observational Study on Cancer Patients. Integr Cancer Ther 2015; 14(5): 452–459. doi:10.1177/1534735415580680. https://www.ncbi.nlm.nih.gov/pubmed/25873294

Anthroposophic Therapy for Migraine: A Two-Year Prospective Cohort Study in Routine Outpatient Settings. Harald J. Hamre, Claudia M. Witt, Gunver S. Kienle, Anja Glockmann, Renatus Ziegler, Andreas Rivoir, Stefan N. Willich and Helmut Kiene. The Open Neurology Journal, 2010; Volume 4:100-110.

Obstetrics and Gynecology

Sleep quality in pregnancy during treatment with Bryophyllum pinnatum: An observational study. Lambrigger-Steiner C, Simões-Wüst AP, Kuck A, Fürer K, Hamburgere M and von Mandach U. Phytomedicine 2014; 21: 753–757. http://dx.doi.org/10.1016/j.phymed.2013.11.003

Effect of Bryophyllum pinnatum versus fenoterol on uterine contractility. Gwehenberger B, Rist L, Huch R, von Mandach U: Eur J Obstet Gynecol Reprod Biol 2004; 113(2):164-71.

Oncology

Intravenous Mistletoe Treatment in Integrative Cancer Care: A Qualitative Study Exploring the Procedures, Concepts, and Observations of Expert Doctors. Kienle GS, Mussler M, Dieter Fuchs and Kiene H. Evidence-Based Complementary and Alternative Medicine, Volume 2016, Article ID 4628287, http://dx.doi.org/10.1155/2016/4628287

Health services research of integrative oncology in palliative care of patients with advanced pancreatic cancer. Axtner J , Steele M, Kröz M, Spahn G, Matthes H and Schad F. BMC Cancer (2016) 16:579 DOI 10.1186/s12885-016-2594-5. https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2594-5

Do we have predictors of therapy responsiveness for a multimodal therapy concept and aerobic training in breast cancer survivors with chronic cancer-related fatigue?
Kröz, M.; Reif, M.; Zerm, R.; Winter, K.; Schad. F.; Gutenbrunner, C.; Girke, M.; Bartsch, C. 2015. Do we have predictors of therapy responsiveness for a multimodal therapy concept and aerobic training in breast cancer survivors with chronic cancerrelated fatigue? Eur J Cancer Care (Engl) 2015; 24(5): 707–717. doi:10.1111/ecc.12278. https://www.ncbi.nlm.nih.gov/pubmed/25602030

Mistletoe: From Basic Research to Clinical Outcomes in Cancer and Other Indications. Kröz M, Kienle GS, Feder G, Kaveri S and Rosenzweig S. Editorial. Evidence-Based Complementary and Alternative Medicine 2014, Article ID 987527. http://dx.doi.org/10.1155/2014/987527

Use and Safety of Intratumoral Application of European Mistletoe (Viscum album L) Preparations in Oncology.
Steele ML, Axtner J, Happe A, Kröz, M, Matthes, H and Schad F. Integr Cancer Ther March 2015 vol. 14 no. 2 140-148. DOI: 10.1177/1534735414563977 ict.sagepub.com.

Safety of Intravenous Application of Mistletoe (Viscum album L.) Preparations in Oncology: An Observational Study. Steele ML, Axtner J, Happe A, Kröz, Matthes and Schad F. Evidence-Based Complementary and Alternative Medicine, 2014; Article ID 236310. Volume 2014,http://dx.doi.org/10.1155/2014/236310

Interaction of standardized mistletoe (Viscum album) extracts with chemotherapeutic drugs regarding cytostatic and cytotoxic effects in vitro. Weissenstein U , Kunz M , Urech K and Baumgartner S. BMC Complementary and Alternative Medicine 2014, 14 :6 Open access: http://www.biomedcentral.com/1472-6882/14/6

Adverse Drug Reactions and Expected Effects to Therapy with Subcutaneous Mistletoe Extracts (Viscum album L.) in Cancer Patients. Steele ML, Axtner J, Happe A, Kröz M, Matthes H and Schad F. Evidence-Based Complementary and Alternative Medicine Volume 2014, Article ID 724258, 11 pages http://dx.doi.org/10.1155/2014/724258

Viscum album [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: A randomised clinical trial on overall survival. Tröger W, Galun M, Reif A et al. Eur J Cancer (2013) http://dx.doi.org/10.1016/j.ejca.2013.06.043

NCCAM/NCI Phase 1 Study of Mistletoe Extract and Gemcitabine in Patients with Advanced Solid Tumors. Mansky PJ, Wallerstedt DB, Sannes TS et al. Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 964592, http://dx.doi.org/10.1155/2013/964592

Intratumoral Mistletoe (Viscum album L) Therapy in Patients With Unresectable Pancreas Carcinoma - A Retrospective Analysis. Schad F, Axtner J, Buchwald D, Happe A, Popp S, Kröz M and Matthes H. Integr Cancer Ther 2013 DOI: 10.1177/1534735413513637) http://ict.sagepub.com/content/early/2013/12/18/1534735413513637

Network Oncology (NO) – a Clinical Cancer Register for Health Services Research and the Evaluation of Integrative Therapeutic Interventions in Anthroposophic Medicine. Schad F, Axtner J, Happe A, Breitkreuz T, Paxino C, Gutsch J, Matthes B, Debus M, Kröz M, Spahn G, Riess H, von Laue H and Matthes H. Forsch Komplementmed 2013;20:353–360 Published online: October 24, 2013 DOI: 10.1159/000356204 Accessible online at: www.karger.com/fok

Anthroposophic supportive treatment in children with medulloblastoma receiving first-line therapy. Seifert G, Rutkowski S, Jesse P, Madeleyn R, Reif M, Henze G and Längler A. J Pediatr Hematol Oncol 2011;33(3):105-10 read more...

Anthroposophic Medicine in Paediatric Oncology in Germany: Results of a Population-Based Retrospective Parental Survey. Alfred Längler, Claudia Spix, Friedrich Edelhäuser, David D. Martin, Genn Kameda, Peter Kaatsch and Georg Seifert. Pediatr Blood Cancer 2010 DOI 10.1002/pbc. read more...

Retrospective analysis of patients with advanced pancreatic cancer under palliative treatment and additive intratumoral application of viscum album l. F. Schad, D. Buchwald, A. Merkle, S. Popp, M. Kroez, H. Matthes: J Clin Oncol 29: 2011 (suppl; abstract e14538). online:http://abstract.asco.org/AbstView_102_82630.

Evaluation of quality of life/life satisfaction in women with breast cancer in complementary and conventional care. Carlsson M, Arman M, Backman M, Flatters U, Hatschek T, Hamrin E. Acta Oncol. 2004;43(1):27-34.

Influence of Viscum album L (European Mistletoe) Extracts on Quality of Life in Cancer Patients: A Systematic Review of Controlled Clinical Studies.Kienle GS and Kiene H. Integrative Cancer Therapies 2010:1-16.

Molecular mistletoe therapy: friend or foe in established anti-tumor protocols? A multicenter, controlled, retrospective pharmaco-epidemiological study in pancreas cancer. Matthes H, Friedel WE, Bock PR, Zanker KS. Curr Mol Med 2010; 10: 430-9.read more...

Durable tumour responses following primary high dose induction with mistletoe extracts: Two case reports. Orange M, Fonseca M, Lace A, vonLaue HB, Geider S. European Journal of Integrative Medicine 2010;2:63-69.read more...

The influence of self- and autonomic regulation on cancer-related fatigue and distress in breast and colorectal cancer patients - A prospective study.Kröz M, Zerm R, Kuhnert N, Brauer D, Laue HBv, Bockelbrink A, Reif M, Schad F, Feder G, Heckmann C, Laue von S, Willich S, Girke M. European Journal of Integrative Medicine 2009;1(4):182. read more...

Prospective controlled cohort studies on long-therapy of cervical cancer patients with a mistletoe preparation (Iscador). Grossarth-Maticek R, Ziegler R.. Forsch Komplementärmed 2007;14:140-7.

A five-year follow-up of quality of life in women with breast cancer in anthroposophic and conventional care. Carlsson M, Arman M, Backman M, Flatters U, Hatschek T, Hamrin E. eCam 2006.

Coping in women with breast cancer in complementary and conventional care over 5 years measured by the mental adjustment to cancer scale.Carlsson M, Arman M, Backman M, Hamrin E. J Altern Complement Med 2005;11(3):441-447.

Orthopedics and Traumatology

Long-term outcomes of anthroposophic treatment for chronic disease: a four-year follow-up analysis of 1510 patients from a prospective observational study in routine outpatient settings. Hamre HJ, Kiene H, Glockmann A, Ziegler R, Kienle GS. BMC Res Notes 2013;6(269):doi:10.1186/1756-0500-6-269.

Anthroposophic therapies in chronic disease: the Anthroposophic Medicine Outcomes Study (AMOS) Hamre HJ, Becker-Witt C, Glockmann A, Ziegler R, Willich SN, Kiene H. Eur J Med Res. 2004 Jul 30;9(7):351-60. read more.

Anthroposophic therapy for children with chronic disease: a two-year prospective cohort study in routine outpatient settings. Hamre HJ, Witt CM, Kienle GS, Meinecke C, Glockmann A, Willich SN, Kiene H. BMC Pediatr 2009;9:39 read more

Predictors of outcome after 6 and 12 months following anthroposophic therapy for adult outpatients with chronic disease: a secondary analysis from a prospective observational study. Hamre HJ, Witt CM, Kienle GS, Glockmann A, Willich SN, Kiene H. BMC Research Notes 2010 Aug 3;3(218). read more

Long-term outcomes of anthroposophic therapy for chronic low back pain: A two-year follow-up analysis. Hamre HJ, Witt CM, Kienle GS, Glockmann A, Ziegler R, Willich SN, Kiene H. Journal of Pain Research 2009;2:75-85. read more

Outcome of anthroposophic medication therapy in chronic disease: A 12-month prospective cohort study. Hamre HJ, Witt CM, Glockmann A, Ziegler R, Kienle GS, Willich SN, et al. Drug Design, Development and Therapy 2008;2:25-37.

Anthroposophic vs. conventional therapy for chronic low back pain: a prospective comparative study. Hamre H, Witt CM, Glockmann A, Ziegler R, Willich SN, Kiene H. Eur J Med Res 2007;12:302-10.

Anthroposophic medical therapy in chronic disease: a four-year prospective cohort study. Hamre HJ, Witt CM, Glockmann A, Ziegler R, Willich SN, Kiene H. BMC Complement Altern Med 2007;7(10):DOI 10.1186/1472-6882-7-10.

Otorhinolaryngology

Integrative versus Conventional Therapy of Chronic Otitis Media with Effusion and Adenoid Hypertrophyin Children: A Prospective Observational Study. Szoeke H, Maródi M, Sallay Z, Székely B, Sterner MG and  Hegyi G.: Forsch Komplementmed 2016;23:231–239. DOI: 10.1159/000448440. http://www.karger.com/Article/PDF/448440

Use and safety of anthroposophic medications for acute respiratory and ear infections: a prospective cohort study. Hamre HJ, Glockmann A, Fischer M, Riley D, Baars E, Kiene H. . Drug Target Insights 2007;2:209-19.

Pediatrics

Integrative versus Conventional Therapy of Chronic Otitis Media with Effusion and Adenoid Hypertrophyin Children: A Prospective Observational Study. Szoeke H, Maródi M, Sallay Z, Székely B, Sterner MG and  Hegyi G.: Forsch Komplementmed 2016;23:231–239. DOI: 10.1159/000448440. http://www.karger.com/Article/PDF/448440

Improvement of Asthma and Gastroesophageal Reflux Disease With Oral Pulvis stomachicus cum Belladonna, a Combination of Matricaria recutita, Atropa belladonna, Bismuth, and Antimonite: A Pediatric Case Report. von Schoen-Angerer T,  Madeleyn R, Kiene H, Kienle GS, Vagedes J. 2015 http://www.gahmj.com/doi/full/10.7453/gahmj.2015.019

Antibiotic Use in Children with Acute Respiratory or Ear Infections: Prospective Observational Comparison of Anthroposophic and Conventional Treatment under Routine Primary Care Conditions. Hamre HJ, Glockmann A, Schwarz R, Riley DS, Baars EW, Kiene H and Kienle GS. Evidence-Based Complementary and Alternative Medicine Volume 2014 (2014), Article ID 243801, 17 pages Full article open access: http://dx.doi.org/10.1155/2014/243801

Anthroposophic therapy for children with chronic disease: a two-year prospective cohort study in routine outpatient settings. Hamre HJ, Witt CM, Kienle GS, Meinecke C, Glockmann A, Willich SN, Kiene H. BMC Pediatr 2009;9:39 read more

Pediatric Neurology

Anthroposophic therapy for attention deficit hyperactivity: a two-year prospective study in outpatients. Harald J Hamre, Claudia M Witt, Gunver S Kienle, Christoph Meinecke, Anja Glockmann, Renatus Ziegler, Stefan N Willich, Helmut Kiene. International Journal of General Medicine 2010:3 239–253.

Psychiatry

Course of life satisfaction in patients with depressive and addictive disorders after therapeutic intervention. Büssing A, Heusser P, Mundle G: International Journal of Social Psychiatry 2011; first published on March 25, 2011 as doi:10.1177/0020764010390498

Anthroposophic therapy for anxiety disorders: a two-year prospective cohort study in routine outpatient settings. Hamre HJ, Witt CM, Kienle GS, Glockmann A, Ziegler R, Willich SN, Kiene H. Clinical Medicine: Psychiatry 2009;2:17-31 read more...

Pulmonology

Improvement of Asthma and Gastroesophageal Reflux Disease With Oral Pulvis stomachicus cum Belladonna, a Combination of Matricaria recutita, Atropa belladonna, Bismuth, and Antimonite: A Pediatric Case Report. von Schoen-Angerer T,  Madeleyn R, Kiene H, Kienle GS, Vagedes J. 2015 http://www.gahmj.com/doi/full/10.7453/gahmj.2015.019

Antibiotic Use in Children with Acute Respiratory or Ear Infections: Prospective Observational Comparison of Anthroposophic and Conventional Treatment under Routine Primary Care Conditions. Hamre HJ, Glockmann A, Schwarz R, Riley DS, Baars EW, Kiene H and Kienle GS. Evidence-Based Complementary and Alternative Medicine Volume 2014 (2014), Article ID 243801, 17 pages Full article open access: http://dx.doi.org/10.1155/2014/243801

Anthroposophic therapy for asthma: a two-year prospective cohort study in routine outpatient settings. Hamre HJ, Witt CM, Kienle GS, Schnürer C, Glockmann A, Ziegler R, Willich SN, Kiene H.J Asthma Allergy 2009;2:111-28.

Use and safety of anthroposophic medications for acute respiratory and ear infections: a prospective cohort study. Hamre HJ, Glockmann A, Fischer M, Riley D, Baars E, Kiene H. . Drug Target Insights 2007;2:209-19.

Pharmacovigilance, Safety and Quality Control

Use and Safety of Intratumoral Application of European Mistletoe (Viscum album L) Preparations in Oncology.
Steele ML, Axtner J, Happe A, Kröz, M, Matthes, H and Schad F. Integr Cancer Ther March 2015 vol. 14 no. 2 140-148. DOI: 10.1177/1534735414563977 ict.sagepub.com.

Safety of Intravenous Application of Mistletoe (Viscum album L.) Preparations in Oncology: An Observational Study. Steele ML, Axtner J, Happe A, Kröz, Matthes and Schad F. Evidence-Based Complementary and Alternative Medicine, 2014; Article ID 236310. Volume 2014,http://dx.doi.org/10.1155/2014/236310

Interaction of standardized mistletoe (Viscum album) extracts with chemotherapeutic drugs regarding cytostatic and cytotoxic effects in vitro. Weissenstein U , Kunz M , Urech K and Baumgartner S. BMC Complementary and Alternative Medicine 2014, 14 :6 Open access: http://www.biomedcentral.com/1472-6882/14/6

Adverse Drug Reactions and Expected Effects to Therapy with Subcutaneous Mistletoe Extracts (Viscum album L.) in Cancer Patients. Steele ML, Axtner J, Happe A, Kröz M, Matthes H and Schad F. Evidence-Based Complementary and Alternative Medicine Volume 2014, Article ID 724258, 11 pages http://dx.doi.org/10.1155/2014/724258

Network Oncology (NO) – a Clinical Cancer Register for Health Services Research and the Evaluation of Integrative Therapeutic Interventions in Anthroposophic Medicine. Schad F, Axtner J, Happe A, Breitkreuz T, Paxino C, Gutsch J, Matthes B, Debus M, Kröz M, Spahn G, Riess H, von Laue H and Matthes H. Forsch Komplementmed 2013;20:353–360 Published online: October 24, 2013 DOI: 10.1159/000356204 Accessible online at: www.karger.com/fok

Anthroposophic medicine in pediatric primary care: a prospective, multicenter observational study on prescribing patterns. Jeschke E, Ostermann T, Tabali M, Kroz M, Bockelbrink A, Witt CM, Willich SN, Matthes H: Altern Ther Health Med 2011;17:18-28.

Pharmacotherapy of elderly patients in everyday anthroposophic medical practice: a prospective, multicenter observational study. Jeschke E, Ostermann T, Vollmar HC, Tabali M, Kröz M, Bockelbrink A, Witt CM, Willich SN, Matthes H. BMC Geriatrics 2010, 10:48. read more

The treatment of children with anthroposophic medicine in daily primary care - Results of a network study. Jeschke E, Ostermann T, Tabali M, Bockelbrink A, Witt C, Willich S, Matthes H. European Journal of Integrative Medicine 2009;1(4):203. read more

Prescribing practices in the treatment of upper respiratory tract infections in anthroposophic medicine. Jeschke E, Lueke C, Ostermann T, Tabali M, Huebner J, Matthes H. Forsch Komplementärmed 2007;14:207-15.

QuaDoSta - ein frei konfigurierbares System zur Unterstützung multizentrischer Datenerhebungen in medizinischer Versorgung und Forschung. Jeschke E, Schad F, Pissarek J, Matthes B, Albrecht U, Matthes H. GMS Med Inform Biom Epidemiol 2007;3(2):Doc 10.

Safety of homeopathic injectables for subcutaneous administration: a documentation of the experience of prescribing practitioners.Baars EW, Adriaansen-Tennekes R, Eikmans KJ. J Altern Complement Med 2005;11(4):609-616.

Anthroposophic Lifestyle

Allergic disease and sensitization in Steiner school children. Floistrup H, Swartz J, Bergstrom A, Alm JS, Scheynius A, van Hage M, Waser M, Braun-Fahrlander C, Schram-Bijkerk D, Huber M, et al. J Allergy Clin Immunol 2006;117(1):59-66.

Bacterial and fungal agents in house dust and wheeze in children: the PARSIFAL study. Schram-Bijkerk D, Doekes G, Douwes J, Boeve M, Riedler J, Ublagger E, von Mutius E, Benz MR, Pershagen G, van Hage M, et al. Clin Exp Allergy 2005;35(10):1272-1278.

Bacterial and fungal components in house dust of farm children, Rudolf Steiner school children and reference children--the PARSIFAL Study.Schram D, Doekes G, Boeve M, Douwes J, Riedler J, Ublagger E, von Mutius E, Budde J, Pershagen G, Nyberg F, et al. Allergy 2005;60(5):611-618.

An anthroposophic lifestyle and intestinal microflora in infancy. Alm JS, Swartz J, Bjorksten B, Engstrand L, Engstrom J, Kuhn I, Lilja G, Mollby R, Norin, E, Pershagen G, Reinders C, Wreiber K, Scheynius A . Pediatr Allergy Immunol 2002;13(6) :402-11.

Atopy in children of families with an anthroposophic lifestyle. Alm JS, Swartz j, Lilja G, Scheynius A, Pershagen G . Lancet 1999;353(9163) :1485-8.

Eurythmy Therapy

Training effect of eurythmy therapy on specific oscillations of heart rate variability.
Edelhäuser, F.; Minnerop, A.; Trapp, B.; Büssing, A.; Cysarz, D. 2015. Eurythmy therapy increases specific oscillations of heart rate variability. BMC Complement Altern Med 2015: 167. doi:10.1186/s12906-015-0684-6. http://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0684-6

A systematic literature review on the effectiveness of eurythmy therpy.
Lötzke D, Heusser P, Büssing A. J Integr Med. 2015 Jul;13(4):217-30. doi: 10.1016/S2095-4964(15)60163-7. http://www.ncbi.nlm.nih.gov/pubmed/25808905

Eurythmy therapy increases specific oscillations of heart rate variability. Edelhäuser F, Antje Minnerop A, Trapp B, Büssing A 3 and Cysarz D. BMC Complementary and Alternative Medicine (2015) 15:167 DOI 10.1186/s12906-015-0684-6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457978/

Eurythmy Therapy in Anxiety. Schwab J, Murphy J, Andersson P, Lunde G, Kiene H, Hamre HJ, Kienle GS: Alternative Therapies in Health and Medicine 2011;17(4): 58-65. Read more

Inner Correspondence and Peacefulness with Practices among Participants in Eurythmy Therapy and Yoga: A Validation Study. Büsssing A, Edelhäuser F, Weisskircher A, Fouladbakhsh JM and Heusser P. Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 329023, 9 pages doi:10.1155/2011/329023 read more

Therapeutic Eurythmy-movement therapy for children with attention deficit hyperactivity disorder (ADHD): a pilot study. Majorek M, Tuchelmann T, Heusser P. Complement Ther Nurs Midwifery 2004 10(1):46-53.

Effects of complementary eurythmy therapy on heart rate variability. Seifert et al:, Complement Ther Med (2008), doi:10.1016/j.ctim.2008.09.005)

Eurythmy therapy in chronic disease: a four-year propective cohort study. Hamre HJ, Witt CM, Glockmann A, Ziegler R, Willich SN, Kiene H. BMC Public Health 2007;7(61):DOI 10.1186/1471-2458-7-61.

External Applications, Nursing, Massage

Clinical Outcomes of Rhythmical Massage. A Prospective Cohort Study with Swiss Outpatients. Wälchli C, Saltzwedel G, Rist L, Bach-Meguid B, Eberhard J, Decker M and Simões-Wüst AP. Alternative and Complementary Therapies. October 2014, 20(5): 248-258. doi:10.1089/act.2014.20509. http://online.liebertpub.com/doi/abs/10.1089/act.2014.20509

Rhythmical massage therapy in chronic disease: a four-year prospective cohort study. Hamre HJ, Witt CM, Glockmann A, Ziegler R, Willich SN, Kiene H. J Altern Complement Med 2007;13(6):635-42.

Therkleson T, Sherwood P: Patient’s experience of the external therapeutic application of ginger by anthroposophically trained nurses. Indio-Pacific Journal of Phenomenology 2005;4:1-11.

Anthroposophic Art Therapies

Arts Therapies for Anxiety, Depression, and Quality of Life in Breast Cancer Patients: A Systematic Review and Meta-Analysis. Boehm K, Cramer H, Staroszynski T and Ostermann T: Hindawi Publishing Corporation. Evidence-Based Complementary and Alternative Medicine.Volume 2014, Article ID 103297, 9 pages http://dx.doi.org/10.1155/2014/103297

Anthroposophic art therapy in chronic disease: a four-year prospective cohort study. Hamre HJ, Witt CM, Glockmann A, Ziegler R, Willich SN, Kiene H. Explore 2007;3(4):365-71.

Oscillations lf heart rate and respiration synchronize during poetry recitation. Cysarz D, von Bonin D, Lackner H, Heusser P, Moser M, Bettermann H: Am J Physiol Heart Circ Physiol 2004;287:H579-H58

Anthroposophic Medicine as Integrative Medicine

Complementary and alternative medicine for cancer patients: results of the EPAAC survey on integrative oncology centres in Europe. Rossi, E.; Vita, A.; Baccetti, S.; Di Stefano, M.; Voller, F.; Zanobini, A. 2015. Complementary and alternative medicine for cancer patients: results of the EPAAC survey on integrative oncology centres in Europe. Support Care Cancer 23(6): 1795–1806. doi:10.1007/s00520-014-2517-4. https://www.ncbi.nlm.nih.gov/pubmed/25471177

Influence of spirituality on cool down reactions, work engagement, and life satisfaction in anthroposophic health care professionals. Büssing A, Lötzke D, Glöckler M, Heusser P. 2015. Influence of spirituality on cool down reactions, work engagement, and life satisfaction in anthroposophic health care professionals. Evid Based Complement Alternat Med. doi: 10.1155/2015/754814. https://www.hindawi.com/journals/ecam/2015/754814/

Do we have predictors of therapy responsiveness for a multimodal therapy concept and aerobic training in breast cancer survivors with chronic cancer-related fatigue?
Kröz, M.; Reif, M.; Zerm, R.; Winter, K.; Schad. F.; Gutenbrunner, C.; Girke, M.; Bartsch, C. 2015. Do we have predictors of therapy responsiveness for a multimodal therapy concept and aerobic training in breast cancer survivors with chronic cancerrelated fatigue? Eur J Cancer Care (Engl) 2015; 24(5): 707–717. doi:10.1111/ecc.12278. https://www.ncbi.nlm.nih.gov/pubmed/25602030

Antibiotic Use in Children with Acute Respiratory or Ear Infections: Prospective Observational Comparison of Anthroposophic and Conventional Treatment under Routine Primary Care Conditions. Hamre HJ, Glockmann A, Schwarz R, Riley DS, Baars EW, Kiene H and Kienle GS. Evidence-Based Complementary and Alternative Medicine Volume 2014 (2014), Article ID 243801, 17 pages Full article open access: http://dx.doi.org/10.1155/2014/243801

Patients whose GP knows complementary medicine tend to have lower costs and live longer. Peter Kooreman P and Baars EW (2010): Eur J Health Econ DOI 10.1007/s10198-011-0330-2

Anthroposophic Medicine: An Integrative Medical System Originating in Europe. Kienle GS, Albonico H-U, Baars, Hamre HJ, Zimmermann P and Kiene H. Global Adv Health Med. 2013;2(6):20-31. DOI: 10.7453/gahmj.2012.087

Overview of the Publications From the Anthroposophic Medicine Outcomes Study (AMOS): A Whole System Evaluation Study. Hamre HJ, Kiene H, Ziegler R, Tröger W, Meinecke C, Schnürer C, Vögler H, Glockmann A, Kienle S: Global Adv Health Med. 2014;3(1):54-70. DOI: 10.7453/gahmj.2013.010.
Full article: http://www.gahmj.com/doi/pdf/10.7453/gahmj.2013.010

Opposite Drug Prescription and Cost Trajectories following Integrative and Conventional Care for Pain – A Case-Control Study. Sundberg, Petzold M, Kohls N and Falkenberg T. PLoS ONE 2014; 9(5): e96717. doi:10.1371/journal.pone.0096717.

Complementary Therapy Systems and Their Integrative Evaluation. Kienle GS, Albonico H-U, Fischer L, Frei-Erb M, Hamre HJ, Heusser P, Matthiessen PF, Renfer A, Kiene H. Journal of Science and Healing 2011(7/3): 175-187. read more (free download)

Clinical judgement and the medical profession. Gunver S Kienle and Helmut Kiene. Journal of Evaluation in Clinical Practice 2010: doi:10.1111/j.1365-2753.2010.01560.x read more

Mindfulness-Based Stress Reduction (MBSR) for integrative Cancer Care – A summary of evidence. Musial F, Büssing A, Heusser P, Kyung-Eun C, Ostermann T: Forschende Komplementärmedizin 2011; 18: (Online August 8, 2011; DOI: 10.1159/000330714)

The challenges of complexity. Wolf U, Winkler M, Ephraim M, Hamre HJ, Lemann D: Primary Care 2011; 11(10):174-175.

Professional treatment in the context of medical pluralism - A German perspective. Kiene H, Brinkhaus B, Fischer G, Girke M, Hahn EG, Hoppe HD, Jütte R, Kraft K, Klitzsch W, Matthiessen PF, Meister P, Michalsen A, Teut M, Willich SN, Heimpel H. Europaen Journal of Integrative Medicine 2010;2:53-56 read more

A pilot study on the effects of a team building process on the perception of work environment in an integrative hospital for neurological rehabilitation. Ostermann T, Bertram M, Büssing A BMC Complementary and Alternative Medicine 2010; 10, 10 (http://www.biomedcentral.com/1472-6882/10/10: 25-44) (pp. 1-10) read more

An integrative approach of cancer treatment with mistletoe therapy, surgery, irradiation and chemotherapy in CAM settings. Schad F, Merkle A, Hoffmann G, Lenneweit G, Spahn G, Hesse M, Paxino C, Wellmann G, Matthes B, Baute R, Breitkreuz T, Matthes H. European Journal of Integrative Medicine 2009;1(4):184. read more

Integrative medical education: Educational strategies and preliminary evaluation of the Integrated Curriculum for Anthroposophic Medicine (ICURAM). Scheffer C, et al. Patient Educ Couns (2012), read more

Medicinal Systems of Complementary and Alternative Medicine: A Cross-Sectional Survey at a Pediatric Emergency Department. Zuzak J, Zuzak-Siegrist I, Rist L, Staubli G, Simoñes-Wüst AP. The Journal of Alternative and Complementary Medicine, Volume 16, Number 4, 2010, pp. 473-479.

Anthroposophic perspectives in primary care. Cantor IS, Rosenzweig S, Volume 24, Number 4, December 1997.

Further Information/Databases/Links

Forschungsinstitut Havelhöhe, Berlin: www.fih-berlin.de/html/publikationen.html

Lehrstuhl für Medizintheorie, Integrative und Anthroposophische Medizin, Witten/Herdecke: www.uni-wh.de/gesundheit/lehrstuhl-medizintheorie/forschung/

Institute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke, Freiburg: www.ifaemm.de/F5_publi.htm

The Anthroposophic Medicine site: Anthromedics

Suomen Antroposofisen Lääketieteen Lääkäriyhdistys ry SALLY, www.antroposofinenlaaketiede.fi

International Federation of Anthroposophic Medical Associations IVAA, www.ivaa.info

School of Spiritual Science, Medical Section at the GoetheanumMedical Section www.medsektion-goetheanum.org